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Tropoelastin

Tropoelastin

Human Tropoelastin, purified recombinant protein, lyophilized

Tropoelastin product image example

For research applications, e.g. tissue engineering and cell culture.

Product code

Prize (€)

Package size

PQ-TE

from 199.00

1, 10, or 50 mg

PQ-TE-04

please inquire

1 g

Our prices are net prices, i.e. they do not contain value added taxes or customs fees. These taxes have to be paid by the customer.

Ordered products are usually shipped 1-2 business days after receiving the order.

Delivery costs depend on destination and packaging.

Tropoelastin is a highly flexible protein with alternating hydrophilic and hydrophobic domains. In humans, there are 13 isoforms known which are all derived from the ELN gene by alternative splicing. The molecular weight of these individual isoforms ranges from approx. 50 – 70 kDa.

Tropoelastin functions as the soluble precursor molecule of elastin. After its expression in the cell it is secreted and forms aggregates that become cross-linked and incorporated into growing elastic fibers.

 

With a half-life of >70 years elastin is a highly stable protein. Moreover, it is a fundamental component of the extracellular matrix (ECM) of tissues whose function requires flexibility (e.g. blood vessels, heart, lung or skin). Elastin provides elasticity and strength and enables these tissues to return to their original shape after being stretched. Besides that, elastin is also involved in wound healing.

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Due to its immediate turnover into elastic fibers, native tropoelastin is not available in the cell and therefore cannot be purified from tissues. Using recombinant methods, we are able to provide human recombinant tropoelastin as sterile, lyophilized protein of high purity for research applications.​​

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