Protein Analytics and Quality Control
We provide peptide and protein analytical services for quality control of:
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Biopharmaceutical proteins
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Proteins generated by recombinant expression
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Proteins purified from biological material
Our technology allows biological characterization of proteins through intact protein analysis, characterization of proteoforms and detection of unexpected modifications. We offer peptide mapping of biopharmaceuticals, monitoring of quality parameters of the major protein component (identity, sequence integrity and post-translational or chemical modifications) and detection and quantification of sample impurities (host cell protein analysis).
More information
Production of biosimilars and biologically derived pharmaceuticals (e.g. recombinant protein production) requires sophisticated quality control. Mass spectrometry assisted proteomics offers a fast and efficient alternative to methods like western blotting or ELISA. Foremost, it allows you to identify hundreds of proteins with a single experiment. Its high sensitivity enables the accurate and reproducible detection and of even low abundant proteins. Our technology covers different quality control approaches: Discovery proteomics (unbiased detection of proteins, host cell protein analysis, expression profiling, etc.) Targeted proteomics (protein quantification, discrimination between isoforms, expression analyses, determination of degradation products, stoichiometry of protein complexes, post-translational or chemical modifications etc.) Peptide mapping (determination of sequence integrity)
Protein Analytics and Quality Control Services
PQ-PepMap-basic
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Peptide mapping after tryptic digest
Includes sample preparation (tryptic digest), LC-MS/MS, data analysis (list of detected peptides)
Price per sample
€ 500.00
PQ-PepMap-Max
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Extended mapping of peptides generated with different proteases
Includes sample preparation and digest with different proteases, LC-MS/MS, data analysis (list of detected peptides)
Price per sample
€ 1,500.00 - 2,500.00
Custom Assay
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Development and validation of a custom quality control assay
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GMP-transfer for routine testing
Development of custom assays for determination of protein purity, protein integrity (intact mass, degradation products), confirmation of protein sequence (peptide mapping), detection of chemical and post-translational modifications etc.