Phage analytics
We support phage research and development of phage-based therapeutics:
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Quantification of phage proteins
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Determination of virion stoichiometry
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Quality control of therapeutics (HCP detection and quantification)
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Analyses and support from early R&D to routine testing
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GMP-conform procedures
More information
Antimicrobial resistance has increased over the past decades and the reducing efficiency of antibiotics demands for new treatments. Phages are natural antibacterial agents and phage research has received a lot of attention, especially its therapeutic application. As for other biologically derived therapeutics phage-based products demand for sophisticated quality control. Mass spectrometry enables the identification of thousands of proteins in one measurement, enabling the unbiased detection of host contaminant proteins in therapeutic phages and viral vaccines at low setup costs. Our proprietary QconCAT technology allows for quantitative determination of phage proteins and the stoichiometry of virions, measuring up to 50 virus proteins with a single QconCAT reference standard. For example, covering the proteome of phiKZ would demand for 4-6 QconCATs, saving you time preparing complex peptide mixes. Additionally, there is no need for production of specific antibodies, enabling fast assay development. Further reading: Applications of targeted proteomics in systems biology and translational medicine Ebhardt et al. Proteomics. 2015 Sep;15(18):3193-208
Phage Analytics Services
Antibody-free phage analysis
Mass spectrometry analyses enable quantitative analyses of phage subunits as well as quality control of therapeutic phage preparations.
Individual service and support
Receive customized proteomics services and detailed reporting.
Our experienced team provides consulting and support at every stage of the project.
Cost-efficient
Precise quantification at low per-sample cost using our proprietary QconCAT technology.
Scalable
Fast and robust measurements.
From exploratory studies to routine measurements and high throughput analyses.
High sensitivity
Stable, accurate and ultra-sensitive protein analysis with high-end instruments
Antibody-free
Fast method setup by unbiased, antibody-independent protein detection.
Efficient
Measurement in complex matrices
(multiple phages, disturbing chemicals, phage proteins in host cells)