CHOcoCAT - Host cell protein analysis
CHOcoCAT
Targeted measurement and absolute quantification of CHO-derived host cell proteins
Biopharmaceuticals, produced in or purified from appropriate host organisms, require identification and risk analysis of all residual host cell derived contaminations (host cell proteins/HCP).
​
For biopharmaceuticals produced in Chinese Hamster Ovary (CHO) cells, PolyQuant’s CHOcoCAT Kit provides 86 heavy isotope (15N) labeled reference peptides for absolute protein quantification of 29 common and critical CHO-specific host cell proteins (HCP) using LC-MS/MS in nanoFlow.
​
Reference: Jones et al. "High-risk" host cell proteins (HCPs): A multi-company collaborative view Biotechnol Bioeng. 2021 Aug;118(8):2870-2885.
Our technology is compatible with various sample preparation protocols (e. g. in-solution, FASP, SP3) and different machine methods (e.g. DIA/SWATH, PRM/MRM, SureQuant) and enables easy setup of multiprotein methods.​
Other labeling options and bioinformatic support are available upon request. For package sizes suitable for microFlow, please contact us.
​
PolyQuant has established routine protocols for targeted LC-MS/MS measurement of the kit’s peptides. Contact us for sample preparation and measurement service at low cost.
Available Products and Services
Special introductory promotion
-50%
Save -50% on your first CHOcoCAT order by using the promo code "MyFirstCHOcoCAT".
Valid for orders until July 31st, 2025, while supplies last.