QconCAT Kit – cardiovascular diseases
CVDQuant
Detection and absolute quantification of biomarkers linked to cardiovascular diseases.
in human, mouse and rat samples
PolyQuant’s CVD Kit provides 212 reference peptides for absolute protein quantification of 47 plasma proteins linked to cardiovascular diseases and is designed for application in human, mouse and rat samples, by using peptides that are shared between all three organisms. The peptides are grouped according to plasma protein expression levels onto four individual QconCAT proteins.
The protein panel includes biomarker proteins enabling the determination of the risk for developing cardiovascular diseases, but can also be adapted for other diseases.
PolyQuant's CVDQuant Kit can be easily combined with additional standards for other proteins of interest.
Other labeling options and bioinformatic support are available upon request.
PolyQuant has established routine protocols for targeted LC-MS/MS measurement of the kit’s peptides. Contact us for sample preparation and measurement service at low cost.
References
Targeted LC-MS/MS for the evaluation of proteomics biomarkers in the blood of neonates with necrotizing enterocolitis and late-onset sepsis
Chatziioannou et al.,
Analytical and Bioanalytical Chemistry 2018. [PubMed]
Chatziioannou et al. used a subset of PolyQuant’s CVD kit and some additional proteins of interest. They were able to define two panels of three proteins each that allow highly sensitive diagnosis of late-onset sepsis (LOS) and differential diagnosis between LOS and necrotizing enterocolitis.
Targeting Ligand Independent Tropism of siRNA-LNP by Small Molecules for Directed Therapy of Liver or Myeloid Immune Cells
Lin et al.,
Advanced Healthcare Materials 2023. [PubMed]
mRNA-based vaccine research made huge progress during the SARS-CoV-2 pandemic. These vaccines require lipid nanoparticles (LNPs) for stability and to ensure intracellular delivery. To study the mechanism of LNP distribution in the body, Lin et al analysed the proteome of liver tissue and serum in wild type and (Ldlr)-/- mice. They performed untargeted proteomics to detect alterations of protein abundance in serum upon siRNA-LNP administration and targeted proteomics for more in-depth analysis of selected proteins using QconCATs (CVDQuant).